Integrated Sensors, LLC (Palm Beach Gardens, FL):

The company (I-S) enjoys a close, mutually beneficial R&D relationship with its collaborating partners. In 2012, Integrated Sensors (I-S) formalized its collaborative relationship with the University of Michigan and Tel Aviv University via the creation of a Research Consortium between the three parties for the purpose of developing new types of ionizing radiation detectors.  In 2016, I-S entered into an R&D agreement with Loma Linda University on the development of new medical imaging technology. In 2018, I-S initiated collaboration with Michigan State University for demonstration and testing of UFT based beam monitors at NSCL and FRIB.

University of Michigan (Ann Arbor, MI):

The University of Michigan, Department of Physics (UM) is at the forefront of research in high energy physics and maintains prolific activity with CERN (European Organization for Nuclear Research), the world’s largest and most ambitious scientific experiment. UM became interested in the I-S plasma panel sensor (PPS) in 2008 primarily as a possible candidate for future ATLAS detector upgrades at CERN, and in particular as a detector of minimum ionizing particles (MIPs) such as high energy muons. This collaboration has led to investigating other applications for PPS technology, and more recently to the I-S conceived ultra-fast transmission (UFT) beam monitor.

I-S has worked closely with UM on most aspects of UFT and PPS research. UM has contributed primarily in the areas of device testing, electronics readout and modeling / simulations, and has made available to I-S the Michigan Ion Beam Laboratory (MIBL) which includes both 3 MeV and 6 MeV proton accelerators. The UM team has established a dedicated “Detector Laboratory” which includes several UFT and PPS test benches, and has worked closely with I-S on testing and modeling UFT and PPS devices with a variety of radiation sources – e.g. protons, cosmic muons, betas/electrons, thermal neutrons, gammas, and UV-photons. UM researchers include faculty, post-docs, graduate students and a full-time engineering technician, and have co-authored a number of technical papers with I-S. UM currently has two sub-awards from I-S primarily for UFT testing and analysis.

Loma Linda University, School of Medicine (Loma Linda, CA):

In 1990, the LLU Proton Treatment & Research Center became the world’s first hospital-based, patient dedicated proton therapy center. Built by the U.S. Department of Energy’s Fermi National Accelerator Laboratory (Fermilab), it is the world’s smallest variable-energy proton synchrotron. The LLU proton therapy center has treated over 20,000 patients, which is more than any other proton treatment facility in the world. LLU currently has a sub-award from I-S primarily for UFT simulation and analysis activity, with two faculty researchers working with I-S on beam monitors for protons, photons, electrons, ions, and epithermal neutrons.

Michigan State University (East Lansing, MI), NSCL and FRIB:

The campus of Michigan State University (MSU) is the U.S. site for the National Superconducting Cyclotron Laboratory (NSCL) and the DOE Facility for Rare Isotope Beams (FRIB). I-S began its collaboration with scientists at MSU, NSCL and FRIB in 2018, which has led to I-S issuing two DOE sub-awards to MSU for simulations, analysis and testing of UFT beam monitors on the NSCL and FRIB beam lines. The main focus of this program is for development of possibly the world’s widest dynamic range (i.e. ≥10 orders-of-magnitude) beamline detector to monitor particle beam rates from approximately 102 to 1013 particles per second. In addition to its remarkable dynamic range, the UFT beam monitor has an extremely high 2D spatial resolution of ~1 µm, and time-of-flight measurement capability of ~50 ps, with low energy straggling in a high radiation damaging environment – see FRIB graphic/figure above under the “ABOUT” tab. Three of the MSU-NSCL-FRIB faculty and senior technical staff are working with I-S on this project.

Tel Aviv University (Tel Aviv, Israel):

Tel Aviv University, School of Physics and Astronomy (TAU) has worked closely with I-S since 2009, primarily on applications for high energy physics (e.g., CERN-LHC) and has made significant contributions to the PPS development effort including building a gas mixing system for testing different gas mixtures within the PPS detector. They have participated in experimental testing of different PPS detector structures and technology evaluation. Their researchers (including faculty, post-docs and graduate students) have also co-authored papers with I-S and UM on the PPS.

University of California at Santa Cruz (Santa Cruz Institute for Particle Physics):

The Santa Cruz Institute for Particle Physics (SCIPP) is organized as a research unit within the University of California system with a primary focus on experimental and theoretical particle physics including applications to neuroscience and biomedicine. The institute is also recognized as a leader in the development of custom readout electronics and silicon microstrip sensors for state-of-the-art particle detection systems. I-S has partnered with SCIPP since 2016 on the design and fabrication of readout electronics for PPS devices for applications directed at external beam radiation therapy (EBRT) and high energy physics.

University of California, San Francisco (UCSF), Dept. of Radiation Oncology:

UCSF is a leading center of health sciences research, patient care, and education devoted solely to graduate education. It is ranked 3rd among research-oriented medical schools in the U.S., and 3rd for primary care, making it the only U.S. medical school to achieve a top-5 ranking in both categories [1]. The UCSF Department of Radiation Oncology focuses on translation research to bring new discoveries to clinical medicine including treatment by electron, photon and proton beam radiation therapy including FLASH radiotherapy, as well as new simulation methods for physical and biological particle therapy. UCSF has worked with I-S for simulation modeling using both Geant4 and TOPAS, the latter developed at UCSF for medical applications.

[1] U.S. News & World Report, “2017 Best Medical Schools” (retrieved February 21, 2017), 

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